Androglobin (ADGB)

Alternative Name: Calpain-7-Like Protein, C6orf103, Chromosome 6 Open Reading Frame 103, CAPN16, CAPN7L

Target

Active Status: Unknown

Project Phase: Targets and Early Development

User: Female, Male

Mode: Non-hormonal

Description: Androglobin is a novel type of globin whose function in reproduction remains to be determined. Androglobins are speculated to bind oxygen and play a role in both sensing oxygen and detoxifying reactive oxygen species in sperm. In humans and mice, androglobin is predominantly expressed in testis tissue and has demonstrated insensitivity to hypoxia. Preliminary evidence exists for increased expression of ADGB in fertile compared to infertile males.

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