ALDH1a2 Inhibitors

Alternative Name: Inhibitors of Testicular Retinoic Acid Biosynthesis

Active Status: Active

Project Phase: Pre-Clinical and Clinical Development

User: Male

Mode: Non-hormonal

Delivery Method: Oral

Duration Type: Long-acting

Description: ALDH1A2 is an enzyme involved in testicular retinoic acid biosynthesis, that if blocked can arrest spermotogenesis. Small molecule inhibitors of ALDH1A2 are being developed as long-term oral, reversible male contraceptives, based on earlier work on bisdichloroacetyldiamines (BDADs).

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